hrp0082p1-d1-178 | Perinatal and Neonatal Endocrinology | ESPE2014

Pubertal and Adrenal Hormones in Monozygotic Twins with Intra-Twin Birth-Weight Difference

Schulte Sandra , Woelfle Joachim , Bartmann Peter , Hamm Michaela , Stoffel-Wagner Birgit , Schreiner Felix , Gohlke Bettina

Background: Low birth weight, unfavourable intrauterine conditions, and post-natal catch-up growth are associated with a subsequent impact on growth, pubertal development, and metabolic disturbances later in life. Although the start of puberty is genetically determined it might be altered due to environmental influences.Objectives: In a longitudinal study (birth to final height) we observed growth and pubertal development of genetically identical twins b...

hrp0082p2-d1-321 | Diabetes | ESPE2014

Interaction of Pubertal Development and Metabolic Control in 1303 Adolescents with Diabetes Mellitus Type 1

Hamm Michaela , Gohlke Bettina , Wolfle Joachim , Fink Katharina , Konrad Katja , Rohrer Tilman , Hofer Sabine , Holl Reinhard

Background: T1DM may influence growth and pubertal development and vice versa. Delayed pubertal development and reduced final height are known to be associated with inadequate metabolic control. Many factors including insulin resistance during puberty and insufficient adherence may be responsible for increasing HbA1c.Objective: Is pubertal growth spurt associated with an increase of HbA1c? Are there gender differences in metabolic control during...